Ingredient
Quatrefolic®
The Active Folate for Methylation & Energy
A fourth-generation, patented form of folate (5-MTHF glucosamine salt) with superior bioavailability — works even for individuals with MTHFR gene variants.
What is Quatrefolic® Good For?
Quatrefolic® delivers folate in its biologically active form (5-methyltetrahydrofolate/5-MTHF), bypassing enzymatic conversion needs in the body. This matters for individuals with genetic variations like MTHFR polymorphisms who struggle converting synthetic folic acid.
Potential benefits of supplementation
- Promotion of methylation and DNA synthesis to prevent neural tube defects during fetal development
- Prevention of megaloblastic anemia when combined with B12
- Reduction in stroke and myocardial infarction risk by lowering homocysteine levels
- Increased mitochondrial energy production
What is Quatrefolic®?
Folate is a water-soluble B vitamin (B9) essential for one-carbon metabolism, which underpins DNA synthesis and methylation.
Unlike folic acid (requiring metabolic conversion to 5-MTHF), Quatrefolic® provides bioactive folate directly, ensuring effectiveness even in individuals with reduced folate-converting capacity.
Recommended Daily Dose
400 µg
Human clinical data and regulatory guidelines support 400 µg per day, covering the EU NRV for folate and providing sufficient active folate for methylation, homocysteine regulation, and pregnancy support.
Quatrefolic® in Detail
- Clinical Dose
- 400 µg
- Source
- Bioactive folate (5-MTHF glucosamine salt) via fermentation (Gnosis by Lesaffre)
- Technology
- Patented fourth-generation folate — superior solubility, stability, and bioavailability vs. folic acid
- Key Benefits
- Provides folate in a bioavailable form (5-MTHF)
- Effective even in individuals with MTHFR polymorphisms
- Prevents neural tube defects during fetal development
- Reduces risk of stroke and myocardial infarction (via homocysteine reduction)
- Supports energy production in the mitochondria
- Data
- Supported by extensive clinical data on folate and proprietary stability/absorption studies. Peer-reviewed research and regulatory approvals (EU, US, Asia).
Supports
Your Questions About Quatrefolic®
What is Quatrefolic®?
Patented, active folate form (5-MTHF) that bypasses folic acid conversion steps.
What are the benefits?
Supports DNA synthesis, pregnancy health, and cardiovascular protection through homocysteine regulation.
How does it differ from folic acid?
Folic acid requires conversion to 5-MTHF (inefficient in many people); Quatrefolic® delivers bioactive folate directly.
Are there any side effects?
Safe and well-tolerated at recommended doses; excess folate should be avoided without medical supervision.
Can it combine with B vitamins?
Yes—works synergistically with vitamins B6 and B12 in methylation and homocysteine metabolism.
The Science That Supports Us
- 1Castellanos-Sinco, H.B. et al. (2015). Megaloblastic anaemia and B12/folate metabolism. Revista Médica del Hospital General de México.
- 2Crider, K.S. et al. (2012). Folate, DNA methylation mechanisms. Advances in Nutrition.
- 3Ferrazzi, E., Tiso, G. and Di Martino, D. (2020). Comparing folic acid vs. 5-methyltetrahydrofolate in pregnancy. European Journal of Obstetrics & Gynecology.
- 4Henderson, A.M. et al. (2018). 5-methyltetrahydrofolate blood concentration increases. Nutrients.
- 5Imbard, A., Benoist, J.F. and Blom, H.J. (2013). Neural tube defects and methylation. Clinical Chemistry and Laboratory Medicine.
- 6Lamers, Y. et al. (2006). Red blood cell folate increases post-supplementation. The American Journal of Clinical Nutrition.
- 7Zhang, X. et al. (2024). Systematic review on folic acid and stroke prevention. Frontiers in Neurology.
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