Quatrefolic®

The Active Folate for Methylation & Energy

A fourth-generation, patented form of folate (5-MTHF glucosamine salt), clinically studied for its superior bioavailability, stability, and role in methylation, energy production, and pregnancy health.

What is Quatrefolic® Good For?

Quatrefolic® delivers folate in its biologically active form, 5-methyltetrahydrofolate (5-MTHF), bypassing the need for enzymatic conversion in the body. This is critical for individuals with genetic variations (e.g. MTHFR polymorphisms) who cannot efficiently convert synthetic folic acid.

 

Quatrefolic® supplementation may lead to:

  • Promotion of methylation and DNA synthesis and therefore prevent neural tube defects during fetus development
  • Prevention of megaloblastic anemia in combination with B12
  • Reduction in the risk of stroke and myocardial infarction by lowering homocysteine levels
  • Increased energy production in the mitochondria

What is Folate?

Folate is a water-soluble B vitamin (B9) essential for one-carbon metabolism, which underpins DNA synthesis and methylation.

 

Unlike folic acid, which must be metabolised into 5-MTHF, Quatrefolic® provides bioactive folate directly, ensuring effectiveness even in individuals with reduced folate-converting capacity.

What is the Recommended Daily Dose of Quatrefolic®?

Human clinical data and regulatory guidelines recommend 400 µg per day, covering the EU NRV for folate and providing sufficient active folate for methylation, homocysteine regulation, and pregnancy support.

Things to Know

Source

Gnosis by Lesaffre proprietary fermentation technology

Technology

Quatrefolic® glucosamine salt of 5-MTHF which is stable, water-soluble, and highly bioavailable

Region

Manufactured in Europe under pharmaceutical-grade standards

Data

Supported by extensive clinical data on folate and Gnosis’ proprietary stability and absorption studies

Quatrefolic® in Detail

Clinical Dose
Clinical Dose

400 µg

Source
Source

Bioactive folate (5-MTHF glucosamine salt)

Technology
Technology

Patented fourth-generation folate with superior solubility, stability, and bioavailability compared to folic acid and calcium salt forms of 5-MTHF.

Key Benefits
Key Benefits
  • Provides folate in a bioavailable form (5-MTHF)
  • Effective even in individuals with MTHFR polymorphisms
  • Beneficial in the prevention of neural tube defects
  • Reducing the risk of stroke and myocardial infarction
Data
Data

Validated by peer-reviewed research and regulatory approvals globally (EU, US, Asia)

Your Questions About Quatrefolic®

Reach us arrow_forward
Quatrefolic® is a patented, active form of folate (5-MTHF) that bypasses conversion steps required for folic acid.
It supports DNA synthesis, pregnancy health, and cardiovascular protection through homocysteine regulation.
Folic acid requires conversion to 5-MTHF, which is inefficient in many people. Quatrefolic® delivers bioactive folate directly, ensuring effectiveness.
Quatrefolic® is safe and well tolerated at recommended doses. Excess folate intake should be avoided without medical supervision.
Yes, it works synergistically with vitamins B6 and B12 in methylation and homocysteine metabolism.

Discover your formula of ingredients

No two people are the same. That’s why your formula is uniquely yours. We select the most effective ingredients based on your health data, lifestyle, and goals — ensuring your capsules are both efficient and safe.

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References

The Science That Supports Us

Cognitive and Neurological Support

Castellanos-Sinco, H.B. et al. (2015) ‘Megaloblastic anaemia: Folic acid and vitamin B12 metabolism’, Revista Médica Del Hospital General De México, 78(3), pp. 135–143. doi:10.1016/j.hgmx.2015.07.001. 

Mental Health

Crider, K.S. et al. (2012) ‘Folate and DNA methylation: A review of molecular mechanisms and the evidence for folate’s role’, Advances in Nutrition, 3(1), pp. 21–38. doi:10.3945/an.111.000992. 

Nerve Repair

Ferrazzi, E., Tiso, G. and Di Martino, D. (2020) ‘Folic acid versus 5- methyl tetrahydrofolate supplementation in pregnancy’, European Journal of Obstetrics & Gynecology and Reproductive Biology, 253, pp. 312–319. doi:10.1016/j.ejogrb.2020.06.012. 

Immune System Support

Henderson, A.M. et al. (2018) ‘L-5-methyltetrahydrofolate supplementation increases blood folate concentrations to a greater extent than folic acid supplementation in Malaysian women’, The Journal of Nutrition, 148(6), pp. 885–890. doi:10.1093/jn/nxy057. 

Immune System Support

Imbard, A., Benoist, J.-F. and Blom, H. (2013) ‘Neural tube defects, folic acid and methylation’, International Journal of Environmental Research and Public Health, 10(9), pp. 4352–4389. doi:10.3390/ijerph10094352. 

Immune System Support

Lamers, Y. et al. (2006) ‘Red Blood Cell folate concentrations increase more after supplementation with [6 s]-5-methyltetrahydrofolate than with folic acid in women of childbearing age’, The American Journal of Clinical Nutrition, 84(1), pp. 156–161. doi:10.1093/ajcn/84.1.156. 

Immune System Support

Scaglione, F. and Panzavolta, G. (2014) ‘Folate, folic acid and 5-methyltetrahydrofolate are not the same thing’, Xenobiotica, 44(5), pp. 480–488. doi:10.3109/00498254.2013.845705. 

Immune System Support

Turck, D. et al. (2022) ‘Conversion of calcium‐l‐methylfolate and (6s)‐5‐methyltetrahydrofolic acid glucosamine salt into dietary folate equivalents’, EFSA Journal, 20(8). doi:10.2903/j.efsa.2022.7452.

Immune System Support

Zhang, N. et al. (2024) ‘Folic acid supplementation for stroke prevention: A systematic review and meta-analysis of 21 randomized clinical trials worldwide’, Clinical Nutrition, 43(7), pp. 1706–1716. doi:10.1016/j.clnu.2024.05.034.