Citrus Bioflavonoids

The Vascular & Antioxidant Protector

A natural complex of flavonoids extracted from citrus fruits, clinically studied for their role in cardiovascular health, antioxidant defence, and immune support.

What are Citrus Bioflavonoids Good For?

Citrus bioflavonoids are a group of plant compounds found in citrus peels and pulp, including hesperidin, naringin, diosmin, and rutin. These bioactives work have immense scientific evidence to improve circulation, lipid markers and neutralise free radicals.

 

Citrus Bioflavonoid supplementation may lead to:

  • Improvements in cardiovascular health by widening blood vessels in response to increased blood flow
  • Reducing oxidative stress and inflammation (according to mouse model studies)
  • Reduction in blood glucose levels and blood pressure in diabetic patients
  • Beneficial improvements in glucose metabolism, inflammation markers in diabetics who are on metformin treatment
  • Improvements in lipid profiles by reducing low density-lipoprotein (LDL) cholesterol and triglycerides
  • Increase in immune defence during viral infection
  • Skin UVB protection by reducing inflammation and downregulate gene expressions for pigmentation (as demonstrated in laboratory studies)

What are Bioflavonoids?

Bioflavonoids are polyphenolic compounds widely distributed in fruits and vegetables. Citrus-derived flavonoids are particularly well studied for their effects on cardiovascular health and capillary resistance, as well as their ability to enhance the absorption of vitamin C.

What is the Recommended Daily Dose of Citrus Bioflavonoids?

Human studies commonly use 500 mg per day, either alone or in combination with vitamin C, to improve cardiovascular health, antioxidant capacity, and immune defense.

Things to Know

Extracted from

Citrus fruits (peel and pulp, e.g. oranges, lemons, grapefruits)

Technology

Concentrated extracts standardised for key flavonoids such as hesperidin and naringin

Region

Naturally occurring in citrus-growing regions worldwide; widely used in Europe for vascular health supplements

Data

Supported by clinical studies on improved blood circulation, oxidative stress, and immunity

Citrus Bioflavonoids in Detail

Clinical Dose
Clinical Dose

500 mg

Source
Source

Citrus fruit peel and pulp

Technology
Technology

Standardised extraction for consistent levels of key flavonoids (hesperidin, naringin, diosmin, rutin)

Key Benefits
Key Benefits
  • Strengthens capillaries and improves microcirculation
  • Works synergistically with vitamin C to support immune health
  • Provides antioxidant and anti-inflammatory protection
  • Supports collagen stability and skin health
  • Contributes to cardiovascular and metabolic balance
Data
Data

Human studies confirm cardiovascular and antioxidant benefits, as well as improving blood markers for diabetic patients.

Your Questions About Citrus Bioflavonoids

Reach us arrow_forward
They are natural plant compounds from citrus fruits that support vascular integrity, antioxidant defence, and immune health.
They help protect blood vessels, reduce oxidative stress, enhance vitamin C absorption, and support cardiovascular, and immune health.
Unlike isolated antioxidants, citrus bioflavonoids work in synergy with vitamin C and provide a broad spectrum of plant-based protective compounds.
They are generally well tolerated. At high doses, some individuals may experience mild digestive discomfort.
Yes, citrus bioflavanoids may enhance each vitamin C absorption.

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References

The Science That Supports Us

Cognitive and Neurological Support

Bellavite, P. and Donzelli, A. (2020) ‘Hesperidin and SARS-COV-2: New light on the healthy function of citrus fruits’, Antioxidants, 9(8), p. 742. doi:10.3390/antiox9080742.

Mental Health

Cesar, T. et al. (2025) ‘Citrus flavonoid supplement enhances glycemic and metabolic control in prediabetic patients on metformin: A randomized controlled trial’, Frontiers in Nutrition, 12. doi:10.3389/fnut.2025.1639901. 

Nerve Repair

Gandhi, G.R. et al. (2020) ‘Citrus flavonoids as promising phytochemicals targeting diabetes and related complications: A systematic review of in vitro and in vivo studies’, Nutrients, 12(10), p. 2907. doi:10.3390/nu12102907.

Immune System Support

Gupta, A. et al. (2023) ‘A systematic review exploring the mechanisms by which citrus bioflavonoid supplementation benefits blood glucose levels and metabolic complications in type 2 diabetes mellitus’, Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 17(11), p. 102884. doi:10.1016/j.dsx.2023.102884.

Mental Health

Jalili, Farnaz et al. (2024) ‘The effects of citrus flavonoids supplementation on endothelial function: A systematic review and dose–response meta‐analysis of Randomized Clinical Trials’, Phytotherapy Research, 38(6), pp. 2847–2859. doi:10.1002/ptr.8190.

Immune System Support

Sattanathan, K. et al. (2011) ‘Beneficial health effects of rutin supplementation in patients with diabetes mellitus’, Journal of Applied Pharmaceutical Science, 1, p. 227-231.

Cognitive and Neurological Support

Vinson, J. and Bose, P. (1988) ‘Comparative bioavailability to humans of ascorbic acid alone or in a citrus extract’, The American Journal of Clinical Nutrition, 48(3), pp. 601–604. doi:10.1093/ajcn/48.3.601.